Today I’m going to talk about vaccines. Just because I don’t have enough controversy in my life.
(Pictures from here.)
From what I’m seeing in the media these days, there are a lot of people who neither know what a vaccine actually is nor what risk actually is. So, let’s talk about that.
Your body is the culmination of the following evolutionary trends:
- 3.5 billion years since bacteria came about
- Roughly 2 billion years since, Eukaryotes—cells with mitochondria and a nucleus evolved.
- About 1.5 billion years since multicellular life evolved
- About 600 million years since animal life evolved (Ediacaran)
- About 500 million years since the earliest vertebrates evolved
- About 300 million years since mammals evolved
- About 63 million years since primates evolved
- About 8.5 million years since humans split from chimpanzees
- About 3 million years since the evolution of genus Homo
- About .5 million years since the beginning of Homo sapiens.
Once life began, other life began to attack it. At first, it was single-celled organisms against single-celled organisms, but then it was single and multicelled organisms against multicelled organisms. My point is that every organism has had to defend itself against other attacking organisms since the beginning of life.
That defense is deep.
For our purposes, our main line of defense against pathogenic organisms—mostly single-celled pathogens or some multicelled parasites—is the immune system. The immune system is ancient and derives from our constant war with pathogens. There are intracellular immune responses—responses individual cells present against an invader—and extracellular immune responses, where the immune system external to the cell attacks invaders.
It's a good system. People who have had some diseases, such as smallpox, don’t get them again. The immune system remembers the smallpox virus. People who get other diseases, such as coronaviruses, get some immunity, but for reasons not well understood, their bodies forget that immunity. In addition, both viruses and bacteria are living organisms, too, and respond when attacked. For a virus or bacteria, an immune response is an attack. After all, they were just sitting there minding their own business, eating the host, when out of nowhere, a bunch of white blood cells eat them in return.
My point is that bodies are in a continual state of attack. Sure, there are good bacteria, but they aren’t what we’re talking about. There’s no scenario when a staph infection is a good thing.
Because pathogens have been attacking us and being repulsed, they are always working on ways to subvert our defenses. In addition, novel pathogens may not be quickly recognized by our immune system.
Vaccines are mechanisms to tell our immune system to wake up and fight invaders, even when those invaders have not yet been encountered. After all, it’s better to meet smallpox with weapons ready than wake up and discover you’re already at death’s door.
And we are talking about death here. All of the pathogens for which we have vaccines have death counts associated with them. Some are close to 100% deadly—rabies, for example. Some are less. Measles has a death rate of 1-2/1000. However, blindness, seizures, and brain inflammation can also occur. Besides, measles has the lovely trait that it wipes out immune memory. All that built up immune response? Gone.
So, we should not just concentrate on death rate. Other complications are also troubling.
Polio is another fun experience. Like a lot of viral diseases, once infected, there’s not much in the way of treatment. Most infected patients have no symptoms or a mild illness—they’re still infected, mind you. But .1-.5% (1-5/1000) develop some kind of paralysis. This is a big deal since, for paralyzed patients, fatality is 2-5% in children (20-50/1000) or 15-30% (150-300/1000) in adults, depending on the age of the patient. But that’s just death. Those who live have lifetime complications.
I grew up knowing children who had survived polio. Children without function in a leg or an arm. Or both legs—President Roosevelt couldn’t really walk because of polio.
If you look at those graphs at the top, you can see something interesting. It presents death rates for smallpox, polio, and measles. Note that the slope remains constant or increasing until vaccination enters the picture. For modern vaccinations, the death rates—and the rates of disease complications—plummet as soon as a modern vaccine is introduced. Even in the case of smallpox, when Jenner’s vaccine was introduced—as primitive as that was—deaths immediately sloped downward. In all three cases, when modern vaccines were introduced, the death rate went close to zero.
I’ve heard about the whole autism issue. It’s bogus. Even the original author who started this mess has recanted. I can understand that people might be concerned about the “inactive” ingredients. So take them out. But tossing vaccines themselves out because of it is idiocy. The CDC recently blamed the COVID vaccine for 10 child deaths out of 96 between 2021-2024. From what I’ve read, these are also bogus numbers, insofar as they present no real evidence to back them up. 270,227,181 people had at least one dose between 2021-2023. That’s .0000037%. According to this source, 30 million kids have been vaccinated, yielding .000033%. The risk of being struck by lightning is 1/1000000 or .0001%. I’ll take those odds.
Hell, I did take those odds. I did. My wife did. My son did. Most of my friends did. Not all of them. Some I knew that didn't, died.
Every medical procedure, every drug, every drive in the car, every waking day is a risk. You have to look at these risks and evaluate them. Which means looking at reputable sources—which pointedly does not include Orange Voldamort or Brainworm Boy and any associated with them.
But going forward.
The mRNA vaccine wasn’t really intended as a vaccine for COVID-19. It was a whole field of technology known as RNA therapeutics. It came out of some studies in the 90s where RNA encoding specific antigens was injected into tumor-bearing mice to induce an immune response. This was successful. The tumors were, in fact, suppressed. This went on to become an original approach for treating melanoma.
That’s right. This technology was first pointed at cancer. It was redirected into making a vaccine against an infectious disease, but it was always intended to target cancer. There’s been success in pancreatic cancer treatment as well.
It’s not a magic bullet—it’s beginning to look like there is no magic bullet for cancer. But it’s a very effective treatment for some cancers and may be useful in many more. It’s even been found to be effective in some kinds of tissue regeneration.
My point with this whole post is that we let idiots scare us. It is getting harder and harder to find original material to evaluate. It gets swamped in all the comments, remarks, and editorializing about such things. Recently, there were some congressional Democrats who made a video reminding members of the military how they were obligated to disobey illegal orders. Regardless of what you might think about what they did, it took thirty-five minutes for me to find the original video buried under commentary.
But that doesn’t release us from the obligation to make the effort. I spent eight years studying biology of one sort or another and the next forty deep in the software industry. Reading about in vitro and ex vivo transmission, T-cells, and antigens is more familiar to me than most. People who don’t work in a given field and try to argue about it are not necessarily reliable—me, included. But a lot of people who demonstrably have zero qualifications—like Brainworm Boy—like to spout off like they’re an authority.
They are not.
The mRNA technology is very exciting. It’s some of the first actual treatments for things like pancreatic cancer. Yet, this technology is under fire—along with most NIH and NSF funded cancer research—by people who either don’t understand it or are being driven by an agenda.
Don’t fall for this. Go find people working in the field. Look up the Wikipedia articles and then go through the references. Weigh the different opinions. If you find six scientific authorities and five of them say one thing and the sixth says another, sure, number six might have something. But the odds are against it. For every stalwart Ignaz Semmelweis or Alfred Wegener, there are a hundred thousand cranks. Make sure that people who make claims have the brainpower to make them. Random Ph.D.’s don’t count. Celebrities don’t count. I think Neil deGrasse Tyson speaks excellent astrophysics. I get skeptical if he starts discussing immunology. Still, he’s better than Brainworm Boy.
Who does these things: here, here, and here.















