This was not a post I wanted to write.
(Picture from here.)
The post World War II United States—and to a large extent the world—was built on science.
Not just science, mind you. The US was the Big Boss after the war as the only powerful country that wasn’t in one way or another gutted by the war. England was bombed flat. Fance, Germany, Russia, Poland—everyone had to rebuild a country after all that devastation.
We didn’t.
It was pretty clear after the war that science and engineering had helped win it. Engineers build things after scientists discover the underlying principles and formalize them.
The importance of medical research goes all the way back to 1887 with the nascent National Institutes of Health. long pre-dating the war. Truman created the National Science Foundation in 1950 and all through the fifties and sixties, its budget grew.
My point is that there are political forces that recognize the need for both medical (NIH) and non-medical (NSF) research. It’s not the only source of scientific research—there are private grant systems and industrial funding. But more than half of American research funding went through NIH or NSF.
Another interesting thing about the NSF and NIH is they weren’t run by political appointees. Grants were reviewed by fellow scientists, not an administration. Not to say that the political environment didn’t have an effect—remember the War on Cancer? But the grant funding was selected by scientists.
Similarly, there were advisory councils created during the fifties that cycled scientists into executive administrations. This happened in defense. In the FDA. Anywhere that a given administration wanted to understand the science of a given field. I’ve met people on some of those councils and they have said that they were not given a political agenda to follow. Sometimes they were listened to. Sometimes not. Often for political reasons but the scientists were not required adhere to those reasons.
That said, there are also political and cultural forces that don’t like science and don’t like scientists.
I’ve never understood this.
Maybe it’s because science is an attempt to discover how nature actually works rather than how we might think it should work. Politics doesn’t seem to work that way.
(Side note: I tried to study to be a scientist but realized part way through the process that I do not have the patience. Instead, I went into engineering where the principles are better known and the reward for effort quicker. If I help on a rocket project, that rocket is going to go somewhere and do something. (Or it gets cancelled. Been there, too.) I’ve known scientists working on projects that take a week to set up, another week to run, and a third week to get a result. Three weeks to find out if an incremental part of what you’re doing even worked and with the possibility of a misstep at any point along the way derailing the entire effort.
But I admire them. )
Science, then, follows murky paths that may or may not end up being useful.
Take the GLP-1 drugs, for instance. These peptide mimic a hormone system that regulates appetite and insulin action. They were looked at for medical use for years but were frustratingly difficult to work with since they were metabolized almost immediately in the body.
Enter the Gila Monster.
In the 1980s, it was shown that the venom of different reptiles (notably the Gila Monster) caused enlargement of the pancreas. Later, in the 1990s, John Eng found that article and through that might be interesting. He was doing research in diabetes and found the Gila interesting because it could go for long periods without eating and still maintain a constant blood sugar. He analyzed the venom and discovered a compound that resembled GLP-1 but did not degrade. From this, the GLP-1 drug family derived.
CRISPR is a technique for the precise editing of genes. It’s been incredibly useful in the last twenty years. The CRISPR/Cas9 system was discovered in bacteria as an immune system targeting bacteriophages. No one knew when CRISPR was discovered whether it could be turned into a biological tool. That came after the discovery was made and published.
My point here is that you don’t know what research is important until it is. This was the basis of the funding model of NIH and NSF: use a broad brush for basic research. Deny crazy research? Maybe—as long s the definition of “crazy” was clear. Was investigating the properties of Gila Monster venom crazy? Not as it turned out.
So, in my opinion, funding mechanisms like the NSF and NIH should be getting lot more funding over time and not less.
That, unfortunately, is not the case. NSF and NIH funding for years has been essentially flat. Given inflation, that really means the funding has effectively been cut. Scientists have been oddly mistrusted by politicians such as Nixon and Reagan. (A good history is here, but Scientific American has a paywall. Sorry.)
And now the Orange Voldemort.
The most recent budget submitted by the administration to Congress included a 12% cut to NIH and a 54% cut to NSF. Since the start of this administration’s term, many billions have been cut or clawed back. These were awards that had already been given. This included cancer research, social research, immunology research, and many other areas.
No scientific area is safe.
If you look at medical history, the first big success story is public hygiene and public health. The second is vaccines. After these two come everything else.
Vaccines seem to be a curious target for this administration. This doesn’t much surprise me since vaccines have been targets for close to the three hundred years since they were discovered. It does surprise me that both the president of the country and the head of the Department of Health and Human Services—both established institutions dedicated to the welfare of the American people—are so hard over to destroy one of the major mechanisms that successfully keep Americans safe.
He’s gone after the measles vaccine. That’s been a rousing success—for measles.
Further, RFK is especially down on mRNA vaccines. To the point that his Department has suppressed studies that show their effectiveness. Nor will he publicly back his own proposed CDC head when she is in favor of vaccines. Moderna has developed an mRNA based flu vaccine and wants to get FDA review. They’re having trouble. The hidden success story is that the mRNA technology has been successful in vaccinating against cancer. It’s likely that will be denied to the American public. But Europe will get it.
Oh, and those scientific advisory panels I mentioned before? RFK has fired a quarter of them.
Then, the OV signed a new executive order to model the US approach to vaccines after Denmark—a country that has a much more homogenous population, is significantly smaller, and—surprise!—has universal health care. He has—again surprise!—not suggested the US have universal health care. I’m sure Denmark’s guidelines are fine for Denmark. They seem a rational country. Our vaccine guidelines used to be geared to the needs of the American people. Now, not so much.
Also, apparently the OV thinks RFK should be more hard over against vaccines. And he should prove a non-existent connection between vaccines and autism. Good luck with that.
Of course, RFK is a multifaceted problem. He’s also going after antidepressants and mammograms.
Essentially, the OV administration is in the process of destroying medical research.
But don’t think it’s just RFK. RFK is the OV’s sock puppet. Have you noticed how he is so supportive of gas stoves? A group was commissioned to determine the effect of gas stoves on asthma. To do this, they planed to take a population of asthma sufferers that had gas stoves in their home and replace them, measuring the nature of their symptoms before and after. They were part way through the study when the OV pulled the plug on their funding. But these researchers didn’t go down without a fight: they published the results they had. You know? Gas stoves are bad for asthma sufferers.
I pretty much thought that these were the sorts of things the OV would attempt—even if I hadn’t, pulling out of the World Health Organization was a pretty big clue. I had hoped that the institutions would prevent him. I did not expect the complete roll over of both Congress and the Supreme Court.
This isn’t a single administration problem. The OV is trying to change how science is funded. How civil servants are hired. How agencies function. He is trying to set his vision of America—run by and for the rich with charity toward none and avarice as its guiding principle—in stone. Scientists are voting with their feet.
This could be the OV’s greatest gift to science—to China.


